Elevated levels of soluble CD8 molecule in patients with lymphatic filariasis.
Identifieur interne : 00DA29 ( Main/Exploration ); précédent : 00DA28; suivant : 00DA30Elevated levels of soluble CD8 molecule in patients with lymphatic filariasis.
Auteurs : R B Lal [États-Unis] ; R M Ramzy ; A A GadSource :
- Immunology letters [ 0165-2478 ] ; 1990.
Descripteurs français
- KwdFr :
- Anticorps monoclonaux, Antigènes CD8, Antigènes de différenciation des lymphocytes B (sang), Antigènes de différenciation des lymphocytes T (sang), Antigènes de surface (immunologie), Filariose lymphatique (immunologie), Humains, Immunophénotypage, Lymphocytes B (immunologie), Récepteur Fc (sang), Récepteurs aux IgE, Récepteurs à l'interleukine-2 (sang), Sous-populations de lymphocytes (immunologie).
- MESH :
- immunologie : Antigènes de surface, Filariose lymphatique, Lymphocytes B, Sous-populations de lymphocytes.
- sang : Antigènes de différenciation des lymphocytes B, Antigènes de différenciation des lymphocytes T, Récepteur Fc, Récepteurs à l'interleukine-2.
- Anticorps monoclonaux, Antigènes CD8, Humains, Immunophénotypage, Récepteurs aux IgE.
English descriptors
- KwdEn :
- Antibodies, Monoclonal, Antigens, CD8, Antigens, Differentiation, B-Lymphocyte (blood), Antigens, Differentiation, T-Lymphocyte (blood), Antigens, Surface (immunology), B-Lymphocytes (immunology), Elephantiasis, Filarial (immunology), Humans, Immunophenotyping, Lymphocyte Subsets (immunology), Receptors, Fc (blood), Receptors, IgE, Receptors, Interleukin-2 (blood).
- MESH :
- chemical , blood : Antigens, Differentiation, B-Lymphocyte, Antigens, Differentiation, T-Lymphocyte, Receptors, Fc, Receptors, Interleukin-2.
- chemical , immunology : Antigens, Surface.
- chemical : Antibodies, Monoclonal, Antigens, CD8, Receptors, IgE.
- immunology : B-Lymphocytes, Elephantiasis, Filarial, Lymphocyte Subsets.
- Humans, Immunophenotyping.
Abstract
The serum levels of soluble forms of suppressor/cytotoxic cells (sCD8) and interleukin-2 receptor (sCD25) were analyzed in 67 patients with lymphatic filariasis and 28 normal controls. Our results show that patients with lymphatic filariasis have significantly higher levels of sCD8 (p less than 0.05) than the control groups, whereas no such difference was observed for sCD25. Within the patient group, however, those in the chronic lymphatic obstruction (CP) had significantly higher levels of both sCD8 (491 +/- 52 U/ml, p less than 0.001) and sCD25 (293 +/- 36 U/ml; p less than 0.02) than those with asymptomatic microfilaremia (sCD8 344 +/- 32 U/ml; sCD25 190 +/- 10 U/ml, respectively). No statistically significant correlation was observed between the serological levels of sCD8 and the percentage of CD8 on peripheral blood T lymphocytes in any of the patient groups. Evaluation of the activation state of B lymphocyte did not reveal any difference in the cellular expression of B7, or serum levels of soluble CD23 in any of the groups studied. Thus the selective increase of sCD8 in patients with filariasis suggests a possible pathogenic role of the cells involved in the release of this molecule.
PubMed: 2148926
Affiliations:
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Le document en format XML
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levels of soluble CD8 molecule in patients with lymphatic filariasis.</title><author><name sortKey="Lal, R B" sort="Lal, R B" uniqKey="Lal R" first="R B" last="Lal">R B Lal</name><affiliation wicri:level="2"><nlm:affiliation>Division of Tropical Public Health, Uniformed Services University of the Health Sciences, Bethesda, MD.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Division of Tropical Public Health, Uniformed Services University of the Health Sciences, Bethesda</wicri:cityArea></affiliation></author><author><name sortKey="Ramzy, R M" sort="Ramzy, R M" uniqKey="Ramzy R" first="R M" last="Ramzy">R M Ramzy</name></author><author><name sortKey="Gad, A A" sort="Gad, A A" uniqKey="Gad A" first="A A" last="Gad">A A Gad</name></author></analytic><series><title level="j">Immunology letters</title><idno type="ISSN">0165-2478</idno><imprint><date when="1990" type="published">1990</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antibodies, Monoclonal</term><term>Antigens, CD8</term><term>Antigens, Differentiation, B-Lymphocyte (blood)</term><term>Antigens, Differentiation, T-Lymphocyte (blood)</term><term>Antigens, Surface (immunology)</term><term>B-Lymphocytes (immunology)</term><term>Elephantiasis, Filarial (immunology)</term><term>Humans</term><term>Immunophenotyping</term><term>Lymphocyte Subsets (immunology)</term><term>Receptors, Fc (blood)</term><term>Receptors, IgE</term><term>Receptors, Interleukin-2 (blood)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Anticorps monoclonaux</term><term>Antigènes CD8</term><term>Antigènes de différenciation des lymphocytes B (sang)</term><term>Antigènes de différenciation des lymphocytes T (sang)</term><term>Antigènes de surface (immunologie)</term><term>Filariose lymphatique (immunologie)</term><term>Humains</term><term>Immunophénotypage</term><term>Lymphocytes B (immunologie)</term><term>Récepteur Fc (sang)</term><term>Récepteurs aux IgE</term><term>Récepteurs à l'interleukine-2 (sang)</term><term>Sous-populations de lymphocytes (immunologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Antigens, Differentiation, B-Lymphocyte</term><term>Antigens, Differentiation, T-Lymphocyte</term><term>Receptors, Fc</term><term>Receptors, Interleukin-2</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Antigens, Surface</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Antibodies, Monoclonal</term><term>Antigens, CD8</term><term>Receptors, IgE</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Antigènes de surface</term><term>Filariose lymphatique</term><term>Lymphocytes B</term><term>Sous-populations de lymphocytes</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>B-Lymphocytes</term><term>Elephantiasis, Filarial</term><term>Lymphocyte Subsets</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Antigènes de différenciation des lymphocytes B</term><term>Antigènes de différenciation des lymphocytes T</term><term>Récepteur Fc</term><term>Récepteurs à l'interleukine-2</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Humans</term><term>Immunophenotyping</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Anticorps monoclonaux</term><term>Antigènes CD8</term><term>Humains</term><term>Immunophénotypage</term><term>Récepteurs aux IgE</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The serum levels of soluble forms of suppressor/cytotoxic cells (sCD8) and interleukin-2 receptor (sCD25) were analyzed in 67 patients with lymphatic filariasis and 28 normal controls. Our results show that patients with lymphatic filariasis have significantly higher levels of sCD8 (p less than 0.05) than the control groups, whereas no such difference was observed for sCD25. Within the patient group, however, those in the chronic lymphatic obstruction (CP) had significantly higher levels of both sCD8 (491 +/- 52 U/ml, p less than 0.001) and sCD25 (293 +/- 36 U/ml; p less than 0.02) than those with asymptomatic microfilaremia (sCD8 344 +/- 32 U/ml; sCD25 190 +/- 10 U/ml, respectively). No statistically significant correlation was observed between the serological levels of sCD8 and the percentage of CD8 on peripheral blood T lymphocytes in any of the patient groups. Evaluation of the activation state of B lymphocyte did not reveal any difference in the cellular expression of B7, or serum levels of soluble CD23 in any of the groups studied. Thus the selective increase of sCD8 in patients with filariasis suggests a possible pathogenic role of the cells involved in the release of this molecule.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Maryland</li></region></list><tree><noCountry><name sortKey="Gad, A A" sort="Gad, A A" uniqKey="Gad A" first="A A" last="Gad">A A Gad</name><name sortKey="Ramzy, R M" sort="Ramzy, R M" uniqKey="Ramzy R" first="R M" last="Ramzy">R M Ramzy</name></noCountry><country name="États-Unis"><region name="Maryland"><name sortKey="Lal, R B" sort="Lal, R B" uniqKey="Lal R" first="R B" last="Lal">R B Lal</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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